Novel Stimuli-Responsive Pectin-PVP-Functionalized Clay Based Smart Hydrogels for Drug Delivery and Controlled Release Application

Stimuli-responsive drug delivery systems are urgently required for injectable site-specific and release of drugs in a controlled manner. For this purpose, we developed novel pH-sensitive, biodegradable, antimicrobial hydrogels from bio-macromolecule pectin, polyvinylpyrrolidone (PVP), 3-aminopropyl (diethoxy)methyl silane (3-APDEMS), sepiolite clay via blending solution casting technique. The purified (40 um) was functionalized with 3-APDEMS crosslinker ( ex-situ modification) followed by fabrication. FTIR SEM confirmed crosslinked structural integrity rod-like morphology respectively. swelling properties could be varying the concentration modified pectin/PVP blends. Moreover, decrease pH increased indicating pH-responsiveness hydrogels. All were degraded after 21 days phosphate buffer saline 7.4 (human blood pH). In-vitro cytotoxicity against 3T3 mouse fibroblast cell line analysis cytocompatibility all Ceftriaxone sodium (CTX-S) selected as model drug. profile hydrogel showed 91.82% PBS 2 h consistent chemical structure remained intact during through UV-Visible spectroscopy. Overall, these used potential scaffolds future biomedical applications.